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dc.contributor.authorUllah, S.
dc.contributor.authorHasan, Z.
dc.contributor.authorZorriehzahra, M.J.
dc.contributor.authorAhmad, S.
dc.coverage.spatialPakistanen_US
dc.date.accessioned2018-03-06T12:32:42Z
dc.date.available2018-03-06T12:32:42Z
dc.date.issued2017
dc.identifier.issn1562-2916
dc.identifier.urihttp://hdl.handle.net/1834/12149
dc.description.abstractUse of different pesticides in the agriculture sector, in order to boost crop yield within a short time period and low labor, has been tremendously increased since the last decade. Pesticide use has elevated crop yield but has produced a number of pronounced problems regarding environmental and health safety. The continuously deteriorating toxicological effects of these pesticides are not only hazardous to humans and land animals but also to economically important aquatic organisms such as fish. One of these extensively used pesticides is an organochlorine insecticide, endosulfan. Experiments conducted in the past have shown the deleterious effects of endosulfan on different aspects of various fish species but its genetic toxicity has not been well studied. The present study was conducted to diagnose the DNA damage induced by endosulfan in peripheral blood erythrocytes of an economically important teleost fish rohu, Labeo rohita (Hamilton, 1822) using comet assay. The fish were exposed to three different sub lethal concentrations (1, 1.5 and 2 µg L-1) of endosulfan for 7, 14, 21 and 28 days. Rohu showed different extents of DNA damage at different concentrations and time, in terms of genetic damage index (GDI), percentage of damaged cells (% damaged cell) and cumulative tail length (µm) of the comets. Increase in DNA damage was observed to be concentration and time-dependent. The current study revealed the severe genotoxic effects of endosulfan in rohu, Labeo rohita. Therefore its discriminate use should be avoided as it can contribute to the decline of rohu in natural habitats. Also it should be considered as a hazardous threat for human consumption.en_US
dc.language.isoenen_US
dc.subject.otherGeneticsen_US
dc.titleDiagnosis of endosulfan induced DNA damage in rohu (Labeo rohita, Hamilton) using comet assayen_US
dc.typeJournal Contributionen_US
dc.bibliographicCitation.issue1en_US
dc.bibliographicCitation.titleIranian Journal of Fisheries Scienceen_US
dc.bibliographicCitation.volume16en_US
dc.description.statusPublisheden_US
dc.format.pagerangepp.138-149en_US
dc.subject.asfaEndosulfanen_US
dc.subject.asfaDNA damageen_US
dc.subject.asfaErythrocyteen_US
dc.subject.asfaComet assayen_US
dc.subject.asfaRohuen_US
dc.type.refereedRefereeden_US
refterms.dateFOA2021-01-30T18:48:17Z


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